|
Prostatic Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
Xenobiotic-metabolizing gene variants, pesticide use, and the risk of prostate cancer.
|
21716162 |
2011 |
|
Cardiomyopathy, Dilated
|
0.120 |
GeneticVariation
|
group |
BEFREE |
Mutations in TXNRD2 produced familial glucocorticoid deficiency (FGD) and dilated cardiomyopathy (DCM).
|
29709707 |
2018 |
|
Cardiomyopathy, Dilated
|
0.120 |
GeneticVariation
|
group |
BEFREE |
Cardiac-specific deletion of Txnrd2 in mice results in dilated cardiomyopathy (DCM).
|
21247928 |
2011 |
|
Cardiomyopathy, Dilated
|
0.120 |
Biomarker
|
group |
HPO |
|
|
|
|
Myopathy
|
0.100 |
Biomarker
|
group |
HPO |
|
|
|
|
Intellectual Disability
|
0.100 |
Biomarker
|
group |
HPO |
|
|
|
|
Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
With TRβ as a tumor suppressor and Runx2 as a tumor promoter, a compelling question is whether there is a functional relationship between these regulatory factors in thyroid tumorigenesis.
|
27253998 |
2016 |
|
Neoplasms
|
0.090 |
AlteredExpression
|
group |
BEFREE |
The thyroid hormone receptor TRβ increases NCoR expression and this induction is essential in mediating the anti-metastatic and tumor suppressive actions of the receptor.
|
27149915 |
2016 |
|
Neoplasms
|
0.090 |
AlteredExpression
|
group |
BEFREE |
Therefore, BRG1-mediated chromatin remodeling may be obligatory for TRβ transcriptional repression and tumor suppressor function in thyroid tumorigenesis.
|
29750276 |
2018 |
|
Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
The miRNAs reduced in TRα1/TRβ knockout mice are known to play crucial roles in epidermal proliferation, hair cycling, wound healing, stem-cell function, and tumor development, all processes altered in the absence of TRs.
|
29742977 |
2018 |
|
Neoplasms
|
0.090 |
AlteredExpression
|
group |
BEFREE |
Importantly, new vessel formation was significantly suppressed in tumors induced by FTC cells expressing TRβ compared with control FTC cells without TRβ.
|
23731250 |
2014 |
|
Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
These finding indicate that TRβ is a tumor suppressor and could be tested as a potential therapeutic target.
|
23183175 |
2013 |
|
Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
We evaluated the role of TRβ in triple-negative breast cancer cell lines representing group 5 tumors.
|
25820519 |
2015 |
|
Neoplasms
|
0.090 |
GeneticVariation
|
group |
BEFREE |
The TR beta gene locus is present and unrearranged in the tumor genome.
|
9226219 |
1997 |
|
Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
The ThrbPV mutation further markedly augmented the risk of mammary hyperplasia in a mouse model with high susceptibility to mammary tumors (Pten(+/-) mouse), as demonstrated by the occurrence of mammary hyperplasia in ∼60% of Thrb(PV/+)Pten(+/-) and ∼77% of Thrb(PV/PV)Pten(+/-) mice versus ∼33% of Thrb(+/+)Pten(+/-) mice.
|
21399657 |
2011 |
|
Malignant Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
We stably expressed the THRB gene in FTC cells and evaluated the effects of the expressed TRβ on cancer cell proliferation, migration, and tumor growth in cell-based studies and xenograft models.
|
23731250 |
2014 |
|
Malignant Neoplasms
|
0.040 |
GeneticVariation
|
group |
BEFREE |
A direct demonstration that TRβ mutants could function as oncogenes is evidenced by the spontaneous development of follicular thyroid carcinoma similar to human cancer in a knockin mouse model harboring a mutated TRβ (denoted as PV; Thrb(PV/PV) mice).
|
21473875 |
2011 |
|
Malignant Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
The anti-cancer activity of mitocurcumin measured in terms of apoptotic cell death and the decrease in cancer stem cell frequency was accentuated by TrxR2 overexpression.
|
29080841 |
2017 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
The TRβ protein was abundant in the cytoplasm of the 786-O, Caki-2, RCC6, and SKRC-45 cells and in the nucleus of SKRC-42, ACHN, 769-P and cancer stem cells.
|
27632932 |
2016 |
|
Primary malignant neoplasm
|
0.040 |
GeneticVariation
|
group |
BEFREE |
A direct demonstration that TRβ mutants could function as oncogenes is evidenced by the spontaneous development of follicular thyroid carcinoma similar to human cancer in a knockin mouse model harboring a mutated TRβ (denoted as PV; Thrb(PV/PV) mice).
|
21473875 |
2011 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
The TRβ protein was abundant in the cytoplasm of the 786-O, Caki-2, RCC6, and SKRC-45 cells and in the nucleus of SKRC-42, ACHN, 769-P and cancer stem cells.
|
27632932 |
2016 |
|
Primary malignant neoplasm
|
0.040 |
AlteredExpression
|
group |
BEFREE |
We stably expressed the THRB gene in FTC cells and evaluated the effects of the expressed TRβ on cancer cell proliferation, migration, and tumor growth in cell-based studies and xenograft models.
|
23731250 |
2014 |
|
Primary malignant neoplasm
|
0.040 |
AlteredExpression
|
group |
BEFREE |
The anti-cancer activity of mitocurcumin measured in terms of apoptotic cell death and the decrease in cancer stem cell frequency was accentuated by TrxR2 overexpression.
|
29080841 |
2017 |
|
Mammary Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Since the thyroid hormone receptor β (TRβ) appears to suppress breast tumor growth and metastasis, we have analyzed the possibility that TRβ could affect the CSC population using MCF-7 cells grown under adherent conditions or as mammospheres, as well as inoculation into immunodeficient mice.
|
31760908 |
2020 |
|
Mammary Neoplasms
|
0.020 |
GeneticVariation
|
group |
BEFREE |
To explore the role of TRβ mutants in vivo in breast tumor development and progression, we took advantage of a knock-in mouse model harboring a mutation in the Thrb gene encoding TRβ (Thrb(PV) mouse).
|
21399657 |
2011 |